The long-term effects of cyclizine exposure during pregnancy
Cyclizine is an antihistamine that is used to treat nausea, vomiting, and dizziness. It is also used to treat motion sickness and vertigo. Cyclizine is in a class of medications called antihistamines. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction.
Cyclizine is used to treat nausea, vomiting, and dizziness caused by motion sickness. It is also used to treat vertigo (false sense of spinning or tilting of the environment). Cyclizine is also used to prevent and treat nausea and vomiting caused by certain medications used to treat Parkinson disease. Cyclizine is in a class of medications called antihistamines. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction.
Cyclizine may be used for purposes not listed in this medication guide.
You should not use this medicine if you are allergic to cyclizine or to similar medications such as meclizine (Antivert, Bonine, Dramamine II, D-Vert), or diphenhydramine (Benadryl, commencing allergy, Dimetapp, and others).
To make sure this medicine is safe for you, tell your doctor if you have ever had:
liver disease;
kidney disease;
glaucoma;
a blockage in your intestines;
seizures;
a urinary tract infection;
enlargement of your prostate; or
problems with urination.
Cyclizine is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
Do not give this medicine to a child without medical advice.
It is not known whether cyclizine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using this medicine.
This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
Avoid drinking alcohol. It can increase some of the side effects of cyclizine.
Taking cyclizine with other drugs that make you drowsy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.
Other drugs may affect cyclizine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using..Read Full Report
Cyclizine and the risk of congenital anomalies
Introduction
Cyclizine is an antihistamine that is used to treat nausea and vomiting. It is also sometimes used to treat vertigo. Cyclizine is in a class of medications called antihistamines. It works by blocking a chemical that is produced by the body during an allergic reaction.
Cyclizine is used to treat nausea, vomiting, and dizziness associated with motion sickness and vertigo.
Cyclizine may also be used for purposes not listed in this medication guide.
Important Information
You should not use cyclizine if you are allergic to it, or if you have glaucoma, urination problems, or severe constipation.
To make sure cyclizine is safe for you, tell your doctor if you have any of these other conditions:
asthma, bronchitis, COPD, or other breathing disorders;
a blockage in your stomach or intestines;
a kidney or liver disease;
epilepsy or other seizure disorder;
a history of mental illness or alcoholism; or
if you regularly take sedatives or tranquilizers.
FDA pregnancy category C. It is not known whether cyclizine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Cyclizine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Do not give this medication to a child younger than 2 years old.
How should I take cyclizine?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results.
Cyclizine is usually taken 3 times per day. Follow your doctor’s instructions.
Do not take more of this medication than recommended for your age. An overdose of cyclizine can be fatal.
Call your doctor if you vomit blood or have black, tarry stools.
Store at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Cyclizine side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using cyclizine and call your doctor at once if you have any of these serious side effects:
confusion, hallucinations;
dizziness, drowsiness, loss of coordination;
fast, pounding, or uneven heartbeats;
seizure (convulsions);
a light-headed feeling, like you might pass out;
little or no urinating;
jaundice (yellowing of the skin or eyes);
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or
severe skin reaction — fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Less serious side effects may be more likely, and you may have none at all.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Cyclizine dosing information
Usual Adult Dose for Nausea/Vomiting:
25 to 100 mg orally 3 to 4 times a day as needed
Comments:
-A lower initial dose (25 mg) is recommended for geriatric patients.
-A maximum daily dose has not been established.
Uses: For the management of nausea, vomiting, and dizziness associated with motion sickness and for the prevention and treatment ofVertigo of central or peripheral origin
Usual Pediatric Dose for Nausea/Vomiting:
Less than 2 years: Safety and efficacy have not been established
2 to 12 years:
Initial dose: 1 mg/kg (up to 50 mg) orally once
Maintenance dose: 1 mg/kg (up to 50 mg) orally 3 to 4 times a day as needed
Maximum dose: 4 mg/kg/day (up to 200 mg/day)
Comments:
-A lower initial dose (1 mg/kg up to 25 mg) is recommended for geriatric, debilitated, cachectic, and malnourished patients.
Uses: For the management of nausea, vomiting, and dizziness associated with motion sickness
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include seizure (convulsions), drowsiness, widened pupils, dry mouth, fever, skin rash, irritability, stomach pain, difficulty urinating, or slow heart rate.
What should I avoid while taking cyclizine?
Avoid becoming overheated or dehydrated during exercise and in hot weather. Cyclizine can decrease sweating and you may be more likely to get heat stroke.
Do not drink alcohol. It can increase some of the side effects of cyclizine.
Cyclizine will make it harder for your body to absorb other medications you take by mouth. Avoid taking other medications within 2 hours before or 2 hours after you take cyclizine.
Cyclizine side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using cyclizine and call your doctor at once if you have any of these serious side effects:
confusion, hallucinations;
dizziness, drowsiness, loss of coordination;
fast, pounding, or uneven heartbeats;
seizure (convulsions);
a light-headed feeling, like you might pass out;
little or no urinating;
jaundice (yellowing of the skin or eyes);
nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or
severe skin reaction — fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.
Less serious side effects may be more likely, and you may have none at all.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Cyclizine dosing information
Usual Adult Dose for Nausea/Vomiting:
25 to 100 mg orally 3 to 4 times a day as needed
Comments:
-A lower initial dose (25 mg) is recommended for geriatric patients.
-A maximum daily dose has not been established.
Uses: For the management of nausea, vomiting, and dizziness associated with motion sickness and for the prevention and treatment ofVertigo of central or peripheral origin
Usual Pediatric Dose for Nausea/Vomiting:
Less than 2 years: Safety and efficacy have not been established
2 to 12 years:
Initial dose: 1 mg/kg (up to 50 mg) orally once
Maintenance dose: 1 mg/kg (up to 50 mg) orally 3 to 4 times a day as needed
Maximum dose: 4 mg/kg/day (up to 200 mg/day)
Comments:
-A lower initial dose (1 mg/kg up to 25 mg) is recommended for geriatric, debilitated, cachectic, and malnourished patients.
Uses: For the management of nausea, vomiting, and dizziness associated with motion sickness
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include seizure (convulsions), drowsiness, widened pupils, dry mouth, fever, skin rash, irritability, stomach pain, difficulty urinating, or slow heart rate.
What should I avoid while taking cyclizine?
Avoid becoming overheated or dehydrated during exercise and in hot weather. Cyclizine can decrease sweating and you may be more likely to get heat stroke.
Do not drink alcohol. It can increase some of the side effects of cyclizine.
Cyclizine will make it harder for your body to absorb other medications you take by mouth. Avoid taking other medications within 2 hours before or 2 hours after you take cyclizine.
Cyclizine precautions
Before taking cyclizine, tell your doctor or pharmacist if you are allergic to it; or to meclizine; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: asthma, bronchitis, COPD, difficulty urinating, epilepsy or other seizure disorder, glaucoma, kidney disease, liver disease, stomach/intestine blockage (such as pyloric stenosis), stomach problems (such as ulcers, diabetes, returned gut after surgery), mental/mood disorders (such as schizophrenia, alcoholism), sedatives or tranquilizers.
This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages.
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.
Cyclizine may pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
Do not give this medication to a child without medical advice.
Older adults may be more sensitive to the side effects of this drug, especially drowsiness, dizziness, confusion, constipation, or trouble urinating. Drowsiness and confusion can increase the risk of falling.
Visit pregnancysicknesssuport.org.uk to learn more about cyclizine when pregnant. Disclaimer: We used this website as a reference for this blog post.